Our Collaborators
Go Beyond Genetics.
Get a Personalized Health Plan
Physician-reviewed with online consultation. Combine genetics, health history and lifestyle. Prevent don't treat.
100% HSA / FSA Eligible
Trusted by Top Clinics
HIPAA Compliant · CLIA/CAP Accredited
80%
of heart attacks are preventable
5
conditions assessed in one test
1M+
genetic variants analyzed
The benefits
Why take the OpenDNA test
Understand your heart and metabolic disease predispositions, holistically
Consult with a licensed physician
Focus your longevity plan on what matters most to you personally
Make informed decisions with your physician about lifestyle changes and preventive medications, such as statins, blood pressure medications, and smoking cessation drugs
Know your predisposition to obesity to make better decisions about GLP-1 weight-loss medications
OpenDNA Health
Use your polygenic and clinical data to better understand your risks and build a targeted prevention plan
Understand your genetic risk for common conditions and take proactive steps for better health and condition prevention. This at-home test analyzes your DNA to provide personalized risk insights reviewed by certified physicians.
Simple. Accurate. From the comfort of your home.
Your report
Clear, actionable insights — not just data
Your report translates complex polygenic data into plain-language explanations your doctor can act on immediately.
Polygenic + clinical risk scores
Our models combine your genetic variants with clinical factors for more accurate prediction than genetics or bloodwork alone.
Physician consultation included
Add a video consultation with a licensed physician who reviews your results and builds a personalized prevention plan with you.
Physician-ready PDF
Share a clinician-formatted version of your results directly with your GP or cardiologist to start the conversation.
Interactive risk explorer
Through your personal portal, explore how lifestyle changes — quitting smoking, increasing exercise, adjusting weight, blood pressure, or cholesterol — interactively shift your risk level in real time.
The research
Validated predictive models
Our models are built on peer-reviewed research and validated against large population cohorts. Each risk score is calibrated to reflect your risk relative to the general population, giving you a meaningful benchmark for proactive action.
Explore the research behind our models
Simple process
Four steps to understanding your heart health
From swab to personalized action plan — all from home, supported by a board-certified physician licensed in your state.
01
Order online
Choose your test and optionally add an expert genetic consultation. Kit ships to your door in 2–3 days.
02
Collect your sample
A simple cheek swab at home — no needles, no clinic visit. Register your kit online and mail it back in the prepaid envelope.
03
Model analysis
Our platform analyzes over one million genetic variants using polygenic risk scores combined with your clinical profile.
04
Your personalized report
Access your full report and optional video consultation with a licensed physician to discuss your results and next steps.
What we assess
5 conditions. One test.
Our test goes far beyond cholesterol checks, assessing your polygenic risk across the full cardiometabolic spectrum.
Heart disease
Type 2 diabetes
Hypertension
High cholesterol
Obesity
Heart disease
Type 2 diabetes
Hypertension
High cholesterol
Obesity
80%
of heart attacks are preventable with early identification and proactive care.
Source: American College of Cardiology, 2023
See the science behind our test →We analyze over one million genetic variants across your DNA, combined into polygenic risk scores — a measure of your individual genetic tendency for each condition, based on the latest large-scale genomic research.
The science
What is a Polygenic Risk Score?
A PRS estimates an individual's inherited likelihood for a condition by combining the effects of many genetic variants across the genome — capturing cumulative risk that single-gene tests cannot detect.
OpenDNA's models are built on millions of variants drawn from large-scale genomic research, delivering broad population coverage and strong predictive accuracy beyond what any single biomarker can provide.
1M+
Genetic variants analyzed
5
Conditions assessed
500K+
Research participants underpinning our models
"By partnering with OpenDNA, we can now offer genetic screening that empowers our patients to take proactive steps towards managing their health and preventing future illness."
Dr. William Harper
CEO & Founder, Harper Health
Our Mission
Bridging the gap between genomics and preventive care
Genomic data holds enormous potential for preventing conditions — yet it remains largely absent from everyday clinical decisions. Our mission is to bridge that gap: integrating polygenic and clinical information into unified models that empower individuals and physicians to understand personal health risks and act on them before a condition develops.
What drives us
The pillars of our approach
Genetics at the core
Your DNA carries signals about future health risks that are detectable today. We translate complex genomic science into clear, personalized risk assessments you can act on.
Clinical context matters
Genetic signals become far more powerful when combined with clinical data. Our models integrate both to deliver insights that reflect your full health picture.
Outcomes that matter
We measure success by real-world impact — lives saved, conditions prevented, and healthcare costs reduced through timely, informed decisions.
Transforming preventive medicine — globally
Our integrated genetic and clinical models have the potential to save lives, improve quality outcomes, and reduce healthcare expenses for individuals and systems worldwide.
Our expertise
Where genomics and clinical medicine meet
Our team brings together deep expertise in genomics and clinical medicine — united by a shared goal of transforming how cardiometabolic disease risk is assessed, communicated, and managed.
© 2026 OpenDNA · Personalized prevention for everyone